Small Organic Carbonic Anhydrase IX Ligands from DNA-Encoded Chemical Libraries for Tumor-Targeted Delivery of Radionuclides
OncoCAIX demonstrated rapid and selective tumor uptake, which is a key feature for the development of radionuclide-based imaging agents for early and late-stage ccRCC and hypoxic tumors.
Authors
- Jacqueline Mock (ORCID: https://orcid.org/0000-0002-4618-1113)
- Dario Neri (ORCID: https://orcid.org/0000-0001-5234-7370)
- Samuele Cazzamalli (ORCID: https://orcid.org/0000-0003-0510-5664)
- Tony Georgiev (ORCID: https://orcid.org/0000-0001-8888-7096)
- Sebastian Oehler (ORCID: https://orcid.org/0000-0003-2013-7381)
- Marco Müller (ORCID: https://orcid.org/0009-0009-7277-1246)
Institutions
- ETH Zurich (CH)
- Philogen (Italy) (IT)
- Philochem (Switzerland) (CH)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1021/jacs.5c05198
- Citations
- 13
- Primary Topic
- Enzyme function and inhibition
- Type
- article
- Field-Weighted Citation Impact
- 10.48