Progressive repigmentation of hypopigmented lesions in discoid lupus erythematosus with anifrolumab: A report of two cases
We report two cases of patients with refractory discoid lupus erythematosus (DLE) and dark skin phototypes who experienced progressive perifollicular repigmentation of depigmented lesions under anifrolumab therapy, with sustained improvement over 18 months. These observations highlight a potential novel effect of anifrolumab on cicatricial dyspigmentation in DLE. This effect may represent a valuable therapeutic option for DLE-related damage, particularly in patients with darker skin types.
Authors
- Alexis Mathian (ORCID: https://orcid.org/0000-0002-7653-6528)
- Katia Boniface (ORCID: https://orcid.org/0000-0003-4428-1222)
- Léa Jaume (ORCID: https://orcid.org/0000-0002-1968-0275)
- Zahir Amoura (ORCID: https://orcid.org/0000-0003-0292-9043)
- A. Barbaud (ORCID: https://orcid.org/0000-0001-8889-1589)
- A. Le Seac’h (ORCID: https://orcid.org/0000-0002-0550-7703)
- Julien Sénéschal (ORCID: https://orcid.org/0000-0003-1139-0908)
- François Chasset
- M. Hulin
Institutions
- Université de Bordeaux (FR)
- Inserm (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Saint-André (FR)
- Centre d'Immunologie et des Maladies Infectieuses (FR)
- Hôpital Tenon (FR)
Publication Details
- Journal
- Lupus
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1177/09612033251345017
- Citations
- 2
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 3.34