The Whole History of the Isolation of Anandamide

The discovery of cannabinoid receptors in human beings led Raphael Mechoulam to realize that the receptors were present in the body not for cannabis-derived compounds but rather for naturally occurring endogenous substances. This paper is a firsthand account of the research that led to the discovery of the first endogenous ligand for these receptors—the discovery of anandamide.

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Publication Details

Journal
Bulletin for the history of chemistry
Published
2025-01-01
DOI
https://doi.org/10.70359/bhc2025v050p057
Primary Topic
Computational Drug Discovery Methods
Type
article
Field-Weighted Citation Impact
0.00
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article

The Whole History of the Isolation of Anandamide

Lumir Ondreg Hanus
Bulletin for the history of chemistry
Computational Drug Discovery Methods
article

The Whole History of the Isolation of Anandamide

Lumir Ondreg Hanus
article en

Abstract

The discovery of cannabinoid receptors in human beings led Raphael Mechoulam to realize that the receptors were present in the body not for cannabis-derived compounds but rather for naturally occurring endogenous substances. This paper is a firsthand account of the research that led to the discovery of the first endogenous ligand for these receptors—the discovery of anandamide.

Bulletin for the history of chemistryVol. 50(1)
Openalex Percentile: Top 88%
Computational Drug Discovery Methods
DOISourceOpenAlex
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The Whole History of the Isolation of Anandamide — Lumir Ondreg Hanus · Bulletin for the history of chemistry (2025) | TGRS Research Map | TGRS