Phase II Study (NO LIMIT, WJOG13320G) of First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability–High Advanced Gastric or Esophagogastric Junction Cancer
NIVO plus LD-IPI showed robust and durable antitumor efficacy as a first-line treatment for MSI-H AGC. Although TRAEs often led to treatment discontinuation, treatment efficacy was subsequently sustained in most patients.
Authors
- Hisato Kawakami (ORCID: https://orcid.org/0000-0002-3280-4850)
- Narikazu Boku (ORCID: https://orcid.org/0000-0002-1438-707X)
- Kenro Hirata (ORCID: https://orcid.org/0000-0003-4536-7781)
- Kazuhiro Kakimi (ORCID: https://orcid.org/0000-0003-2631-3040)
- Yasutaka Chiba (ORCID: https://orcid.org/0000-0002-7261-2351)
- Yukari Kobayashi (ORCID: https://orcid.org/0000-0002-2600-2181)
- Masahiro Tsuda (ORCID: https://orcid.org/0000-0001-6442-9250)
- Hiroki Hara (ORCID: https://orcid.org/0000-0003-3881-9815)
- Hidekazu Hirano (ORCID: https://orcid.org/0000-0003-1343-1419)
- Shigenori Kadowaki (ORCID: https://orcid.org/0000-0001-9923-5309)
- Yoshito Komatsu (ORCID: https://orcid.org/0000-0002-1570-6802)
- Taito Esaki (ORCID: https://orcid.org/0000-0002-9169-8453)
- K. Muro
- Akitaka Makiyama (ORCID: https://orcid.org/0000-0002-4017-668X)
- Nozomu Machida (ORCID: https://orcid.org/0000-0001-9570-3670)
- Naotoshi Sugimoto (ORCID: https://orcid.org/0000-0003-1995-5002)
- Shuichi Hironaka (ORCID: https://orcid.org/0000-0001-9714-231X)
- Ichinosuke Hyodo (ORCID: https://orcid.org/0000-0001-8210-0731)
Institutions
- Kyorin University (JP)
- Tohoku University (JP)
- Keio University (JP)
- Kanagawa Prefectural Hospital Organization (JP)
- National Hospital Organization Kyushu Cancer Center (JP)
- Kindai University Hospital (JP)
- Gifu University Hospital (JP)
- Saitama Cancer Center (JP)
- Aichi Cancer Center (JP)
- Shikoku Cancer Center (JP)
- Hokkaido University Hospital (JP)
- National Cancer Center Hospital East (JP)
- Osaka International Cancer Institute (JP)
- Hyogo Prefectural Cancer Center (JP)
- Gifu University (JP)
- Kanagawa Cancer Center
- The University of Tokyo (JP)
- Kindai University (JP)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1200/jco-24-02463
- Citations
- 10
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 10.45