Ouhanamide, an Antiparasitic Linear Lipopeptide from a Marine <i>Okeania</i> sp. Cyanobacterium
Ouhanamide (<b>1</b>), a new linear lipopeptide consisting of a long-chain fatty acid with a β-branched methyl group, was isolated from a marine <i>Okeania</i> sp. cyanobacterium. The overall structure was elucidated by a combination of various spectroscopic analyses, degradation reactions, and derivatizations. Ouhanamide (<b>1</b>) showed selective antiparasitic activity (IC<sub>50</sub> = 1.2 ± 0.1 μM against <i>Trypanosoma brucei rhodesiense</i> and IC<sub>50</sub> = 4.2 ± 0.9 μM against <i>Plasmodium falciparum</i>) without cytotoxicity at 10 μM against HeLa cells.
Authors
- Kiyotake Suenaga (ORCID: https://orcid.org/0000-0001-5343-5890)
- Ghulam Jeelani (ORCID: https://orcid.org/0000-0003-0816-9831)
- Tomoyoshi Nozaki (ORCID: https://orcid.org/0000-0003-1354-5133)
- Naoaki Kurisawa (ORCID: https://orcid.org/0000-0002-3204-7693)
- Mayumi Niiyama
- Adnan Luthfi Agusta
- Kairi Umeda
Institutions
- Keio University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c00281
- Citations
- 4
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 4.93
Funders
- Keio University
- Amano Institute of Technology
- Japan Society for the Promotion of Science