Comparison of the Diagnostic Performance of the Central Vein Sign and CSF Oligoclonal Bands Supporting the Diagnosis of Multiple Sclerosis
The central vein sign (CVS) describes the presence of venules within multiple sclerosis (MS) brain lesions, visible on T2*-weighted MRI. In the upcoming revision of the MS diagnostic criteria, the simplified “rule of 6” (i.e., finding 6 lesions with a central venule) can support the diagnosis of MS as an alternative to lumbar puncture (LP). We evaluated whether a T2*-weighted MRI scan is more sensitive than oligoclonal bands (OCBs) for diagnosing MS at presentation with a typical clinically isolated syndrome (CIS). We also compared the tolerability of LP and the additional MRI.
Authors
- Nikos Evangelou (ORCID: https://orcid.org/0000-0003-2871-0672)
- Emma Tallantyre (ORCID: https://orcid.org/0000-0002-3760-6634)
- Roshan das Nair (ORCID: https://orcid.org/0000-0001-8143-7893)
- Bader Mohamed (ORCID: https://orcid.org/0000-0002-4544-9448)
- Robert A. Dineen (ORCID: https://orcid.org/0000-0002-9523-2546)
- Zin Min Htet
- Kimberley Allen‐Philbey (ORCID: https://orcid.org/0000-0003-1207-8625)
- Klaus Schmierer (ORCID: https://orcid.org/0000-0002-9293-8893)
- Hyunjoo Pai (ORCID: https://orcid.org/0000-0003-4143-035X)
- Margareta A. Clarke (ORCID: https://orcid.org/0000-0001-5531-796X)
- Deborah Fitzsimmons (ORCID: https://orcid.org/0000-0002-7286-8410)
- Christopher Allen (ORCID: https://orcid.org/0000-0002-8225-8747)
- Paul S. Morgan (ORCID: https://orcid.org/0000-0002-5870-1446)
- Marija Cauchi (ORCID: https://orcid.org/0000-0001-7793-271X)
- Jonathan Hawken
- Christopher Partlett
Institutions
- University of Nottingham (GB)
- Queen Mary University of London (GB)
- SINTEF (NO)
- Barts Health NHS Trust (GB)
- Mater Dei Hospital (MT)
- Nottinghamshire Healthcare NHS Foundation Trust (GB)
- Swansea University (GB)
- Nottingham Biomedical Research Centre (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Neurology Open Access
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1212/wn9.0000000000000017
- Citations
- 3
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Institute for Health and Care Research