Inhibition of VE-PTP rejuvenates Schlemm’s canal in aged mice and acts via Tie2
Interference with VE-PTP function improves SC function in a strictly Tie2 dependent way and pharmacologic inhibition of VE-PTP with AKB9778 is a promising approach for improving SC function in the aged eye.
Authors
- Dietmar Vestweber (ORCID: https://orcid.org/0000-0002-3517-732X)
- Astrid F. Nottebaum (ORCID: https://orcid.org/0000-0003-2246-7851)
- Ute Ipe (ORCID: https://orcid.org/0000-0002-8177-2680)
- Kevin G. Peters (ORCID: https://orcid.org/0000-0003-4717-4828)
- S Mishra (ORCID: https://orcid.org/0000-0003-2817-5681)
Institutions
- Aerpio Pharmaceuticals (United States) (US)
- Max Planck Institute for Molecular Biomedicine (DE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1371/journal.pone.0323615
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Max-Planck-Gesellschaft