Effectiveness of a reduced dose of ready-to-use therapeutic food in community-based management of severe acute malnutrition: A non-inferiority randomized controlled trial in the Democratic Republic of Congo
The strategy of a reduced RUTF dose starting from the third week of treatment is as effective as the standard dose strategy on weight gain velocity and programmatic outcomes in a context of severe food insecurity. However, MUAC gain velocity was lower in the reduced dose group. Future studies should investigate the effectiveness of a reduced dose strategy among sub group of children with high risk factors. Trial registration: International Standard Randomized Controlled Trial Network (ISRCTN15258669).
Authors
- Alemayehu Argaw (ORCID: https://orcid.org/0000-0003-3982-5408)
- Sophie Bruneau
- Florence Mbiya Muadi
- Samuel Mampunza Ma Miezi
- Julien Ntaongo Alendi (ORCID: https://orcid.org/0000-0003-0624-7189)
- Cécile Salpéteur (ORCID: https://orcid.org/0000-0002-8135-6169)
- Steve Botomba (ORCID: https://orcid.org/0000-0003-3355-7449)
- Benjamin Guesdon (ORCID: https://orcid.org/0000-0002-2876-0533)
- Victor Nikièma (ORCID: https://orcid.org/0000-0001-8334-8579)
- Marie‐Claire Muyer
- Uwimana Sebinwa
- Jean-Baptiste Mayavanga
- Marie Petry
- Aimée Mupuala Masaya
Institutions
- Ministry of Public Health (CD)
- Ghent University (BE)
- University of Kinshasa (CD)
- Action Contre la Faim (FR)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1371/journal.pmed.1004606
- Citations
- 6
- Primary Topic
- Child Nutrition and Water Access
- Type
- article
- Field-Weighted Citation Impact
- 6.72
Funders
- Action Contre La Faim