Correlation between histologic chorioamnionitis and severe retinopathy of prematurity
Retinopathy of prematurity (ROP) is influenced by numerous perinatal and postnatal factors, including low gestational age, oxygen exposure, and chorioamnionitis. However, the association between chorioamnionitis and ROP remains controversial. Our study showed that histologic chorioamnionitis (HCA) was negatively correlated with severe ROP in preterm infants, even after adjusting for confounding factors such as gestational age and birth weight. These findings suggest that HCA may have a protective effect against severe ROP, potentially mediated by inflammatory markers.
Authors
- Ee‐Kyung Kim (ORCID: https://orcid.org/0000-0002-7063-168X)
- Seung Han Shin (ORCID: https://orcid.org/0000-0002-7008-4073)
- Han‐Suk Kim (ORCID: https://orcid.org/0000-0002-9777-3231)
- Chan‐Wook Park (ORCID: https://orcid.org/0000-0002-1290-6438)
- Young Mi Yoon (ORCID: https://orcid.org/0000-0002-3274-3883)
Institutions
- Chungnam National University (KR)
- Seoul National University Hospital (KR)
- Seoul National University Children's Hospital (KR)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1038/s41390-025-04093-y
- Citations
- 1
- Primary Topic
- Retinopathy of Prematurity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Seoul National University
- Seoul National University Hospital
- Korea National Institute of Health