Four new cytotoxic triterpenoids from <i>Euphorbia fischeriana</i>
Our ongoing phytochemical investigation on <i>Euphorbia fischeriana</i> led to isolation of four new cytotoxic triterpenoids (<b>1-4</b>), along with twenty three known analogues (<b>5-27</b>). The new structures were characterised as fiseuphanins C-F (<b>1-4</b>) by NMR and HRESIMS spectroscopic experiments. Among them, isolates <b>8-15</b>, <b>17-20</b>, <b>22</b>, and <b>25-27</b> were the first examples from <i>E. fischeriana.</i> Compounds <b>2</b>, <b>11</b>, and <b>13</b> exhibited significant cytotoxic activity against MCF-7 cell line with IC<sub>50</sub> of 0.04, 6.30, and 2.44 µM, respectively, whereas, only compounds <b>6</b>, <b>8</b>, <b>11</b>, and <b>23</b> exhibited weak inhibitory activity against A549 with IC<sub>50</sub> values ranging from 36.37 to 81.49 µM.
Authors
- Ting-Xiang Shi
- Yuan-Biao He
- Yong Zhao (ORCID: https://orcid.org/0000-0002-3996-2480)
- Yu-Ping Huang (ORCID: https://orcid.org/0000-0001-6423-949X)
- Jing Yang (ORCID: https://orcid.org/0000-0002-6680-7486)
- Yanni Ma (ORCID: https://orcid.org/0009-0006-7863-9375)
- Wen-Na Li
Institutions
- Yunnan Normal University (CN)
- Kunming Institute of Botany (CN)
- Chinese Academy of Sciences (CN)
- Kunming Municipal Hospital of Traditional Chinese Medicine (CN)
- Yunnan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1080/14786419.2025.2503015
- Primary Topic
- Bioactive Natural Diterpenoids Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China