Optimizing pediatric status epilepticus management: The role of early midazolam infusion and adherence to clinical practice guidelines
This study emphasizes that low-dose midazolam infusion, not requiring endotracheal intubation and administered at an early phase, appears to be effective in permanently stopping seizure and preventing the evolution toward a refractory CSE. Given its proven efficacy and widespread use in many hospitals, early midazolam infusion could be considered in the management of pediatric CSE. Adherence to treatment protocols, specific etiologies, and type of CSE are correlated with refractoriness; thus, when facing SE in infants, these factors should guide treatment protocol selection, including medication choice and timing.
Authors
- Maria Cristina Mondardini (ORCID: https://orcid.org/0000-0002-8398-3166)
- Anna Rosati (ORCID: https://orcid.org/0000-0002-8754-7214)
- Alessandro Simonini (ORCID: https://orcid.org/0000-0003-3788-7672)
- Silvia Pulitanò (ORCID: https://orcid.org/0000-0001-6815-6421)
- Luca Bergonzini (ORCID: https://orcid.org/0000-0001-8214-1816)
- Patrizia Bartolotta (ORCID: https://orcid.org/0000-0001-9779-8298)
- Fabrizio Chiusolo (ORCID: https://orcid.org/0000-0003-0265-609X)
- Francesca Darra (ORCID: https://orcid.org/0000-0002-1062-8438)
- Domenica Battaglia (ORCID: https://orcid.org/0000-0003-0491-4021)
- Paolo Biban (ORCID: https://orcid.org/0000-0001-7073-6265)
- Federico Vigevano (ORCID: https://orcid.org/0000-0001-7513-0051)
- Duccio Maria Cordelli (ORCID: https://orcid.org/0000-0002-1367-6419)
- Manuela L’Erario (ORCID: https://orcid.org/0000-0002-9827-6771)
- Roberta Vittorini (ORCID: https://orcid.org/0000-0002-7026-1762)
- Alessandra Conio
- Emanuele Giacheri (ORCID: https://orcid.org/0000-0001-9417-317X)
- Claudia Bonardi (ORCID: https://orcid.org/0000-0002-6266-3665)
- Elisabetta Cesaroni (ORCID: https://orcid.org/0000-0002-7177-4500)
- Lucia Fusco (ORCID: https://orcid.org/0000-0002-9573-102X)
- Angela Amigoni (ORCID: https://orcid.org/0000-0001-5654-0506)
- Nicola Specchio (ORCID: https://orcid.org/0000-0002-8120-0287)
- Sara Olivotto (ORCID: https://orcid.org/0000-0003-2612-1727)
- Jacopo Proietti (ORCID: https://orcid.org/0000-0002-5584-4724)
- Silvia Buratti (ORCID: https://orcid.org/0009-0003-3321-2907)
- Caterina Zanus (ORCID: https://orcid.org/0000-0001-7235-4965)
- Clarissa Tona
- Massimo Mastrangelo
- Paola Costa (ORCID: https://orcid.org/0000-0003-0546-6005)
- Stefano Sartori (ORCID: https://orcid.org/0000-0002-0012-6848)
- Carla Marini (ORCID: https://orcid.org/0000-0002-9212-2691)
- Anna Fetta (ORCID: https://orcid.org/0000-0003-0175-6486)
- Francesca Izzo
- Giulia Cannizzaro
- Emmanuele Mongelli
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Verona (IT)
- University of Padua (IT)
- Istituto Giannina Gaslini (IT)
- Agostino Gemelli University Polyclinic (IT)
- IRCCS Policlinico San Donato (IT)
- Provincia Autonoma di Trento (IT)
- Meyer Children's Hospital (IT)
- Azienda USL di Bologna (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Bambino Gesù Children's Hospital (IT)
- Ospedale Regina Margherita (IT)
- Ospedale dei Bambini Vittore Buzzi (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Turin (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1111/epi.18455
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Ministero della Salute