Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic-Resistant Organisms (FERARO): A feasibility randomised controlled trial
Progression to a substantive trial is feasible with modifications to the existing FERARO protocol. FMT was safe, well tolerated, and acceptable to patients colonised with MDRO. Microbiome analysis infers that greater donor-recipient microbiome dissimilarity at baseline and higher rates of donor-derived strain engraftment favour MDRO decolonisation, which in turn maybe facilitated by conspecific strain replacement.
Authors
- Manu Shankar‐Hari (ORCID: https://orcid.org/0000-0002-5338-2538)
- Adrien D. Le Guennec
- Debbie L. Shawcross (ORCID: https://orcid.org/0000-0001-6133-4619)
- Karen Bisnauthsing (ORCID: https://orcid.org/0000-0001-9045-1064)
- Anna L. Goodman (ORCID: https://orcid.org/0000-0003-0643-9017)
- Elizabeth Allen (ORCID: https://orcid.org/0000-0001-6360-7385)
- David L. Moyes (ORCID: https://orcid.org/0000-0002-1657-918X)
- Marc Delord (ORCID: https://orcid.org/0000-0002-0455-6749)
- Maria R. Conte (ORCID: https://orcid.org/0000-0001-8558-2051)
- Simon Goldenberg (ORCID: https://orcid.org/0000-0003-0837-7382)
- Blair Merrick (ORCID: https://orcid.org/0000-0002-6061-6064)
- Jordana T. Bell (ORCID: https://orcid.org/0000-0002-3858-5986)
- Chrysi Sergaki (ORCID: https://orcid.org/0000-0003-0477-8680)
- Abdel Douiri (ORCID: https://orcid.org/0000-0002-4354-4433)
- Michael Kertanegara
- Désirée Prossomariti
Institutions
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Centre for Innovation in Regulatory Science (GB)
- King's College Hospital NHS Foundation Trust (GB)
- Centre for Inflammation Research (GB)
- The Queen's Medical Research Institute (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1016/j.jinf.2025.106504
- Citations
- 11
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 15.36
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- Research for Patient Benefit Programme