Novel function of macrophage migration inhibitory factor in regulating post-infarct inflammation and the therapeutic significance
Deletion of global and inflammatory-cell-derived MIF diminished inflammation following MI by inhibiting monocyte mobilization and downregulating pro-inflammatory mediators, while cardiac-derived MIF exerted anti-inflammatory influence and facilitated healing. Furthermore, MIF antibody therapy protected the heart from severe ischemic injury and improved long-term prognosis.
Authors
- Ling Zhao (ORCID: https://orcid.org/0000-0002-8007-8128)
- Chuanshan Zhang (ORCID: https://orcid.org/0000-0002-3241-2224)
- Guoli Du (ORCID: https://orcid.org/0000-0003-0526-1616)
- Hongzhi Qi (ORCID: https://orcid.org/0000-0001-5719-2718)
- Xiao-Ming Gao (ORCID: https://orcid.org/0009-0007-3510-3105)
- Min‐Tao Gai (ORCID: https://orcid.org/0000-0001-5012-2063)
- Amanguli Ruze
- Bang-Hao Zhao
- Qiulin Li (ORCID: https://orcid.org/0000-0001-6011-1296)
- An-Xia Deng
- Su Hu
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1016/j.jare.2025.05.030
- Citations
- 2
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 1.59