Variable Relative Biological Effectiveness of Protons in the Rat Spinal Cord: Measurements and Comparison With Model Calculations
A fixed RBE of 1.1 provides a good approximation up to the center of the spread-out Bragg peak; however, at 3 mm from the distal end, the RBE increases markedly and may reach values above 1.4 at clinical fraction schedules. Using predictions from a variable RBE model may, therefore, be reasonable; however, the model and model parameters should be carefully selected, ideally as a consensus among the proton therapy centers.
Authors
- Stephan Brons (ORCID: https://orcid.org/0000-0002-4695-0816)
- Lisa Hintz
- Peter Peschke
- M. Scholz (ORCID: https://orcid.org/0000-0002-6382-6737)
- Thomas Friedrich (ORCID: https://orcid.org/0000-0003-0074-6390)
- Christin Glowa (ORCID: https://orcid.org/0000-0002-5557-9799)
- Maria Saager
- Christian P. Karger (ORCID: https://orcid.org/0000-0002-7194-8136)
- Rosemarie Euler-Lange
- Andrea Mairani (ORCID: https://orcid.org/0000-0001-6669-7064)
- Kaya Hilt
- Hans Liew
Institutions
- GSI Helmholtz Centre for Heavy Ion Research (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Heidelberger Institut für Radioonkologie (DE)
- National Center for Oncological Hadrontherapy (IT)
- National Center for Tumor Diseases (DE)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1016/j.adro.2025.101809
- Citations
- 1
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Deutsche Krebshilfe