The systemic immune-inflammation index (SII) as a biomarker for depression in a community sample of adolescents
In this community-based sample of adolescents, greater depressive symptoms were associated with elevated SII and individual white blood cell levels. Future studies using larger, longitudinal clinical samples are needed to confirm the potential role of the SII in adolescent depression, and the involvement of inflammation in early-onset depression.
Authors
- Eric Tu
- Anett Schumacher (ORCID: https://orcid.org/0000-0002-8549-4577)
- Daphne J. Korczak (ORCID: https://orcid.org/0000-0002-0061-7495)
- Carly Albaum (ORCID: https://orcid.org/0000-0002-0011-8813)
Institutions
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Hospital for Sick Children (CA)
Publication Details
- Journal
- Comprehensive Psychoneuroendocrinology
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1016/j.cpnec.2025.100302
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- Hospital for Sick Children
- Garry Hurvitz Centre for Brain and Mental Health
- National Institutes of Health
- National Institute of Mental Health