HMGA2 is an independent prognostic indicator and a potential therapeutic target for IDH-mutant astrocytoma
HMGA2 was highly expressed in recurrent IDH-mutant astrocytoma, with higher expression levels associated with increased cell migration and invasion abilities. HMGA2 has the potential to serve as a biomarker for poor prognosis and may represent an effective therapeutic target in the treatment of IDH-mutant astrocytoma.
Authors
- Shunyao Li (ORCID: https://orcid.org/0009-0002-2110-9243)
- Luying Wan (ORCID: https://orcid.org/0000-0002-4929-5511)
- Ziyi Liu (ORCID: https://orcid.org/0000-0002-5660-9187)
- Zhihui Gao (ORCID: https://orcid.org/0000-0002-9103-4331)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Acta Neurochirurgica
- Published
- 2025-05-17
- DOI
- https://doi.org/10.1007/s00701-025-06548-x
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00