Stereological insights into the protective effects of agmatine on hippocampal damage induced by aluminum nanoparticles
Agmatine exerts potent neuroprotective effects against Al-NP-induced hippocampal toxicity by mitigating memory deficits, preventing neuronal loss, and suppressing apoptosis through downregulation of cleaved caspase-3 and modulation of Bax/Bcl-2 signaling. These structural and molecular changes may underlie its cognitive benefits. Given the role of hippocampal atrophy in AD, agmatine may be a promising candidate for preventing Al-related neurodegeneration and AD progression.
Authors
- Bahar Rostami
- Vahid Reza Ostovan (ORCID: https://orcid.org/0000-0003-2407-5915)
- Zahra Esmaili (ORCID: https://orcid.org/0000-0003-3776-236X)
- Maryam Moosavi (ORCID: https://orcid.org/0000-0001-6943-477X)
- Yosra Abdolahpoor
Institutions
- Shiraz University of Medical Sciences (IR)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1016/j.biopha.2025.118163
- Primary Topic
- Aluminum toxicity and tolerance in plants and animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shiraz University of Medical Sciences
- Vice-Chancellor for Research, Shiraz University of Medical Sciences