Synthesis of Pyrrolidin‐3‐Ones and Spiropyrrolidinones by 1,3‐Dipolar Cycloadditions of Nitrones with Allenylphosphonates
A general and effective (3 + 2) cycloaddition reaction between nitrones and allenes to synthesize fluoro‐phosphonopyrrolidin‐3‐ones, as well as spiropyrrolidin‐3‐one phosphonates is reported under microwave heating. The products have been isolated in moderate to good yields and exclusively as 4,5‐trans diastereoisomers in all transformations.
Authors
- Rayhane Hammami
- Tahar Ayad (ORCID: https://orcid.org/0000-0003-4210-5997)
- Benjamin Darses (ORCID: https://orcid.org/0000-0002-2284-5931)
- Lucas Mele (ORCID: https://orcid.org/0000-0002-6372-6816)
- David Virieux (ORCID: https://orcid.org/0000-0002-6495-9478)
- Soufiane Touil (ORCID: https://orcid.org/0000-0002-2878-5757)
Institutions
- École Nationale Supérieure de Chimie de Montpellier (FR)
- Centre National de la Recherche Scientifique (FR)
- University of Carthage (TN)
- Université de Montpellier (FR)
- Département de Chimie Moléculaire (FR)
- Institut Charles Gerhardt Montpellier (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1002/ejoc.202500390
- Citations
- 4
- Primary Topic
- Phosphorus compounds and reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.74