Deficiency of NPR-C triggers high salt-induced thoracic aortic dissection by impairing mitochondrial homeostasis
Our data highlight a critical role of HSD in triggering TAD and a previously unrecognized role of NPR-C that protects against TAD through regulating mitochondrial homeostasis. Therefore, NPR-C activation and SPD supplementation could be new prevention and treatment strategies for TAD.
Authors
- Ji‐Guang Wang (ORCID: https://orcid.org/0000-0001-8511-1524)
- Wuwei Rong (ORCID: https://orcid.org/0000-0003-0257-1678)
- Jinqiu Wei (ORCID: https://orcid.org/0009-0002-8924-3625)
- Jing Chen (ORCID: https://orcid.org/0000-0002-5763-6902)
- Qi-Fang Huang
- Wei Zhang (ORCID: https://orcid.org/0000-0002-0055-9299)
- Yuan‐Yuan Kang (ORCID: https://orcid.org/0000-0001-9121-5872)
- Wen-Hui Zhai (ORCID: https://orcid.org/0009-0002-6380-2257)
- Jiajia Zhao (ORCID: https://orcid.org/0000-0002-4515-8229)
- Xiaodong Li (ORCID: https://orcid.org/0000-0002-3771-6286)
- Ye Yang (ORCID: https://orcid.org/0000-0001-9344-9349)
- Yi Yang (ORCID: https://orcid.org/0000-0001-8913-0220)
- Zhe Wang (ORCID: https://orcid.org/0000-0003-1032-2743)
- Qian-Wan Deng (ORCID: https://orcid.org/0009-0002-9309-8352)
- Xiao-Fei Ye
- Pingjin Gao (ORCID: https://orcid.org/0000-0002-7750-3314)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Shanghai Institute of Hypertension (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1093/cvr/cvaf085
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China