Fetal Fraction Methodologies and Their Clinical Use: Results of a College of American Pathologists Exercise
Using multiple methods to estimate FF was common, and cutoff levels for sample suitability varied widely. Within-laboratory FFs were less variable than between laboratories. Current FF estimates from clinical laboratories are not standardized and should be considered laboratory-specific.
Authors
- Ross Rowsey
- Nathalie Lepage (ORCID: https://orcid.org/0000-0003-2684-9021)
- Ann M. Moyer (ORCID: https://orcid.org/0000-0003-2590-7218)
- Glenn E. Palomaki (ORCID: https://orcid.org/0000-0001-6154-8449)
- Phillip Michael Cacheris (ORCID: https://orcid.org/0000-0002-3491-0841)
- Marvin R. Natowicz (ORCID: https://orcid.org/0000-0002-3018-546X)
- Thomas Long (ORCID: https://orcid.org/0000-0001-6693-594X)
- Philip Wyatt
Institutions
- Cleveland Clinic (US)
- Mayo Clinic (US)
- College of American Pathologists (US)
- Brown University (US)
- Children's Hospital of Eastern Ontario (CA)
- Newborn Screening Ontario (CA)
- Women & Infants Hospital of Rhode Island (US)
- Sequenom (United States) (US)
Publication Details
- Journal
- The Journal of Applied Laboratory Medicine
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1093/jalm/jfaf062
- Citations
- 1
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 3.49