HBV-driven host chromatin accessibility changes affect liver metabolic pathways, iron homeostasis and promote a preneoplastic phenotype
Altogether our results show that HBV infection impacts on host cell chromatin landscape and specific transcriptional programs including liver metabolism and liver cancer pathways. Re-wiring of iron metabolism boosts viral replication early after infection. The modulation of genes involved in cancer-related pathways may favor the development or the selection of a pro-neoplastic phenotype and persists in HBV-related HCCs.
Authors
- Claude Caron de Fromentel (ORCID: https://orcid.org/0000-0001-7566-3958)
- Vincenzo Alfano (ORCID: https://orcid.org/0000-0002-4981-748X)
- Philippe Merle (ORCID: https://orcid.org/0000-0002-8230-394X)
- Giacomo Corleone (ORCID: https://orcid.org/0000-0002-6170-9780)
- Alexia Paturel (ORCID: https://orcid.org/0000-0001-9288-9131)
- Michel Rivoire
- Giuseppe Rubens Pascucci (ORCID: https://orcid.org/0000-0002-5978-1193)
- Francesca De Nicola (ORCID: https://orcid.org/0000-0002-2187-7544)
- Océane Floriot
- Massimo Levrero (ORCID: https://orcid.org/0000-0002-4978-0875)
- Massimiliano Cocca (ORCID: https://orcid.org/0000-0002-1127-7596)
- Francesca Casuscelli di Tocco
- F. Guerrieri (ORCID: https://orcid.org/0000-0003-2751-6050)
Institutions
- Université catholique de lyon (FR)
- Inserm (FR)
- Italian Institute of Technology (IT)
- Centre de Recherche en Neurosciences de Lyon (FR)
- Hospices Civils de Lyon (FR)
- Centre Léon Bérard (FR)
- Centre de Recherche en Cancérologie de Lyon (FR)
- National Cancer Institute (MY)
- Center for Nano Science and Technology (IT)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1186/s13046-025-03414-7
- Citations
- 2
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Styrelsen för Internationellt Utvecklingssamarbete
- European Commission
- Agence Nationale de la Recherche
- Agence Nationale de Recherches sur le Sida et les Hépatites Virales
- Ligue Contre le Cancer