Enhanced therapeutic effects of all-trans retinoic acid nanostructured lipid carrier composite gel drug delivery system for alopecia areata
ATRA-NLC-Gel enhanced the transdermal permeability and follicle-targeting efficacy of ATRA, alleviated ATRA-induced skin dryness and irritation, and effectively improved the symptoms of AA in AA model mice. ATRA-NLC-Gel offers a highly promising strategy for transdermal treatment of AA in clinical setting.
Authors
- Wangting Li (ORCID: https://orcid.org/0000-0001-7070-5768)
- Feihong Jin (ORCID: https://orcid.org/0000-0002-9403-4169)
- Lingling Zheng (ORCID: https://orcid.org/0000-0002-8447-5446)
- Yanping Yin
- Xuan Zhou (ORCID: https://orcid.org/0000-0002-2930-8514)
- Dong Xu (ORCID: https://orcid.org/0000-0001-5432-6012)
- Yan Weng
- Yang Du
- Lulu Zhang (ORCID: https://orcid.org/0000-0001-9337-9395)
- Jingwen Wang (ORCID: https://orcid.org/0009-0002-6495-0884)
Institutions
- Army Medical University (CN)
- Northwest University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Xijing Hospital (CN)
- Shaanxi University of Chinese Medicine (CN)
- Chongqing Medical University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-05-16
- DOI
- https://doi.org/10.1186/s12951-025-03407-w
- Citations
- 8
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 14.69