Downregulation of CMIP contributes to preeclampsia development by impairing trophoblast function via the PDE7B-cAMP pathway
Our study demonstrates for the first time that the CMIP-PDE7B-cAMP pathway contributes to PE development by influencing trophoblast function. The signaling pathway proteins involved in PE induced by CMIP may provide new clues to the occurrence of PE and new targets for future PE therapy.
Authors
- Xinyuan Zhou (ORCID: https://orcid.org/0000-0002-1374-8240)
- Yang Fang (ORCID: https://orcid.org/0000-0002-4535-457X)
- Qianqian Shi (ORCID: https://orcid.org/0000-0001-8787-8227)
- Xin Wayne Zhao (ORCID: https://orcid.org/0000-0002-1621-2337)
- Yuanbo Zhou (ORCID: https://orcid.org/0000-0002-0136-3503)
- DU Hong-mei (ORCID: https://orcid.org/0000-0001-5461-3900)
- Yang-Nan Ding
- Yujie Yuan (ORCID: https://orcid.org/0000-0001-5786-4377)
- Xinjing Yan
- Linlin Zhang (ORCID: https://orcid.org/0000-0003-0204-7972)
- Haiyang Yu (ORCID: https://orcid.org/0000-0002-5051-8508)
- Yina Li (ORCID: https://orcid.org/0009-0004-9158-5397)
- Yongrui Gao
- Enwu Yuan (ORCID: https://orcid.org/0000-0002-7378-5043)
Institutions
- Zhengzhou University (CN)
- Henan Tianguan Group (China) (CN)
- Shaanxi Blood Center (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1007/s00018-025-05726-5
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06