TMT-based quantitative proteomics analysis of serum-derived exosomes in patients with juvenile gout
The protein composition of serum-derived exosomes in J-Gout was significantly differed from that in J-HUA and oJIA. DPP4 and SERPIND1 were uniquely highly expressed in J-Gout. Some possible mechanisms regarding the inflammatory response and coagulation complement system were proposed, which may provide helpful diagnostic and therapeutic insights for J-Gout.
Authors
- Shanmiao Sun
- Zhuyi Ji
- Ling Liang (ORCID: https://orcid.org/0009-0009-0809-9053)
- Li T (ORCID: https://orcid.org/0000-0001-6438-2691)
- Yukai Huang
- Lixin Huang (ORCID: https://orcid.org/0000-0002-8507-1910)
- Shaoling Zheng
- Yuebing He
- Zhixiang Huang (ORCID: https://orcid.org/0000-0003-0282-8859)
- Xia Pan
Institutions
- Jinan University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- The First People's Hospital of Zhaoqing (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/fendo.2025.1460218
- Citations
- 1
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 1.43