Mirodenafil improves cognitive function by reducing microglial activation and blood–brain barrier permeability in ApoE4 KI mice
These findings suggest that mirodenafil enhances cerebrovascular function, preserves BBB integrity, and mitigates neuroinflammation in ApoE4 KI mice, leading to cognitive improvement. PDE5 inhibition may serve as a promising therapeutic approach for addressing ApoE4-associated cerebrovascular and cognitive dysfunction.
Authors
- Harry Jung (ORCID: https://orcid.org/0000-0002-7691-8403)
- Jong‐Hee Sohn (ORCID: https://orcid.org/0000-0003-2656-9222)
- Yejin Park (ORCID: https://orcid.org/0000-0002-0545-7267)
- Chan Hee Lee (ORCID: https://orcid.org/0000-0001-8791-817X)
- Sang Won Han (ORCID: https://orcid.org/0000-0003-0941-1300)
- Songyi Park (ORCID: https://orcid.org/0000-0001-5817-4845)
- Jiyoung Kim (ORCID: https://orcid.org/0000-0002-2999-3320)
- Subin Moon
- Dan-Gyeong Song
- Yong-Ho In
Institutions
- Hallym University (KR)
- Korea Medicine Research Institute (KR)
- Hallym University Chuncheon Sacred Heart Hospital (KR)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/fnagi.2025.1579411
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68