The effects of a semen cuscutae flavonoids-based antidepressant treatment on microbiome and metabolome in mice
Mice with depression induced by CUMS exhibited disturbances in both their gut microbiota and fecal metabolism. However, SCFs restored the balance of the microbial community and corrected metabolic disturbances in feces, exerting antidepressant effects through a multifaceted mechanism.
Authors
- Jin Lin (ORCID: https://orcid.org/0000-0003-1540-9565)
- Xiaowei Fu
- Jing Wang (ORCID: https://orcid.org/0000-0003-3694-6001)
- Qianfeng Shao
- Yue Li (ORCID: https://orcid.org/0000-0002-7727-905X)
- Shaohui Du (ORCID: https://orcid.org/0000-0002-0247-6112)
- Che Chen (ORCID: https://orcid.org/0000-0001-5156-2431)
- Sheng Zhou (ORCID: https://orcid.org/0000-0001-8896-1006)
- Tong Liu (ORCID: https://orcid.org/0000-0002-1157-8890)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Beijing University of Chinese Medicine (CN)
- Ningxia Medical University (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
- Qingdao Center of Resource Chemistry and New Materials (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/fmicb.2025.1558833
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China