Granulomatous lymphocytic interstitial lung disease in common variable immune deficiency: an in-depth clinical, immunological, functional and radiological exploration with a focus on its management, challenged by chronic CMV infection
This study highlights novel immunological markers and clinical-radiological patterns as potential predictors for GLILD, advocating for their integration into diagnostic and monitoring frameworks to reduce reliance on invasive histopathology. Future research should focus on validating biomarkers and conducting RCTs to establish evidence-based guidelines for GLILD management.
Authors
- Francesco Baccelli (ORCID: https://orcid.org/0000-0001-8313-7288)
- Francesca Conti (ORCID: https://orcid.org/0000-0002-3665-8926)
- M. Bassi
- Aldo Guerrieri
- Mattia Moratti (ORCID: https://orcid.org/0000-0003-1133-9563)
- Gioacchino Schifino (ORCID: https://orcid.org/0009-0002-0308-5698)
- Marcello Lanari (ORCID: https://orcid.org/0000-0002-2586-314X)
- Simona Ferrari
- Elisabetta Magrini
- Maurizio Zompatori
Institutions
- University of Rome Tor Vergata (IT)
- ASL Roma (IT)
- Azienda USL di Bologna (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Villa Torri Hospital (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1589052
- Citations
- 4
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.19