Integrated multi-omics profiling to establish an IGFBP-based prognostic score for pancreatic ductal adenocarcinoma: unraveling prognostic biomarkers, immune microenvironment crosstalk, and therapeutic implications
This study identified the IGFBP family genes as key modulators of PDAC progression and immune landscape remodeling. These findings supported the potential of IGFBP family genes as prognostic biomarkers and therapeutic targets, offering new insights into PDAC biology and opportunities for personalized treatment strategies.
Authors
- Chengfeng Wang (ORCID: https://orcid.org/0009-0009-4415-9789)
- Xiao Guan
- Yongrun Mu
- Xin Jin (ORCID: https://orcid.org/0000-0003-4167-1743)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1600527
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Medical Sciences