TSPAN4+ fibroblasts coordinate metastatic niche assembly through migrasome-driven metabolic reprogramming and stromal-immune crosstalk in pancreatic adenocarcinoma
TSPAN4<sup>+</sup> fibroblasts are key regulators of pancreatic cancer progression, contributing to metastasis, immune suppression, and ECM remodeling. Targeting these fibroblasts represents a promising therapeutic strategy to improve clinical outcomes and enhance the effectiveness of immunotherapies in pancreatic cancer.
Authors
- Qingwen Hu
- Xiaolin Zhong (ORCID: https://orcid.org/0000-0001-5819-4272)
- Xuancheng Zhou (ORCID: https://orcid.org/0009-0003-0700-9382)
- Hao Chi (ORCID: https://orcid.org/0000-0001-6934-3966)
- Yang Liu (ORCID: https://orcid.org/0000-0002-9284-1944)
- Bo Li (ORCID: https://orcid.org/0000-0002-3568-0507)
- Jiali Chen (ORCID: https://orcid.org/0000-0001-7376-3322)
- Lai Jiang (ORCID: https://orcid.org/0000-0002-4639-8136)
- Haotian Lai
- Shengke Zhang
- Jinbang Huang
- Haiqing Chen
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1594879
- Citations
- 6
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 5.23