Changes in microbiome composition after fecal microbiota transplantation via oral gavage and magnetic navigation technology-assisted proximal colon/cecum enema in antibiotic knock-down rats: a comparative experimental study
Fecal microbiota tube placement using magnetic navigation was safe and feasible in rats.Different delivery route for FMT affects the gut microbiota composition and the integrity of the rat intestinal barrier. Future experimental designs should consider the colonization outcomes of critical microbial taxa to determine the optimal FMT delivery routes in scientific research as well as clinical practise.
Authors
- Yingmin Yao
- Lu Ren (ORCID: https://orcid.org/0009-0007-2919-5058)
- Qiang Lu (ORCID: https://orcid.org/0000-0002-8294-4966)
- Lin-Biao Xiang (ORCID: https://orcid.org/0000-0002-1947-587X)
- Yi Lv (ORCID: https://orcid.org/0000-0003-3636-6664)
- Erjun Zhou (ORCID: https://orcid.org/0000-0003-1182-311X)
- Jia Hao (ORCID: https://orcid.org/0000-0002-6763-795X)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-4284-2604)
- Jiawei Yu (ORCID: https://orcid.org/0000-0001-8730-1452)
- YangQuan Chen (ORCID: https://orcid.org/0000-0002-7422-5988)
- Chenxi Yang (ORCID: https://orcid.org/0009-0007-0410-587X)
- Yu-Xuan Liuyang
- Xian-Jie Bai
- Jia-Tong Zhao
- Zhi-Ren Chen
- Xiaojuan Dong
- Yu-Chen Mei
- Zhijie Zhang (ORCID: https://orcid.org/0009-0004-5943-4257)
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s12866-025-04026-z
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Major Research Plan