Neuroprotective effects of astaxanthin in a scopolamine-induced rat model of Alzheimer’s disease through antioxidant/anti-inflammatory pathways and opioid/benzodiazepine receptors: attenuation of Nrf2, NF-κB, and interconnected pathways
Astaxanthin demonstrates protective effects against scopolamine-induced AD through its neuroprotective, antioxidant, and anti-inflammatory properties, potentially involving interactions with opioid and benzodiazepine receptors.
Authors
- Sajad Fakhri (ORCID: https://orcid.org/0000-0001-8265-8284)
- Javier Echeverría (ORCID: https://orcid.org/0000-0002-1688-968X)
- Amir Kiani (ORCID: https://orcid.org/0000-0002-7802-2117)
- Mohammed Namiq Amin
- Mohammad Ranjbarı (ORCID: https://orcid.org/0000-0002-3090-2422)
- Fatemeh Abbaszadeh (ORCID: https://orcid.org/0000-0002-1374-3554)
- Zeinab Rastinpour
Institutions
- Universidad de Santiago de Chile (CL)
- Kermanshah University of Medical Sciences (IR)
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/fphar.2025.1589751
- Citations
- 8
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 9.31
Funders
- Kermanshah University of Medical Sciences