Single cell atlas of canine natural killer cells identifies distinct circulating and tissue resident gene profiles
Together, our results point to heterogeneous canine NK populations highly comparable to human NK cells, and we provide a comprehensive atlas of canine NK cells across organs which will inform future cross-species NK studies and further substantiate the spontaneous canine model to optimize NK immunotherapy across species.
Authors
- Michael S. Kent (ORCID: https://orcid.org/0000-0002-7703-7720)
- Zachary S. Morris (ORCID: https://orcid.org/0000-0001-5558-3547)
- William J. Murphy (ORCID: https://orcid.org/0000-0002-2793-401X)
- David M. Vail (ORCID: https://orcid.org/0000-0002-1964-3693)
- William T. N. Culp (ORCID: https://orcid.org/0000-0001-6132-156X)
- Aryana M. Razmara (ORCID: https://orcid.org/0000-0002-3834-3442)
- Cameron E. Gaskill (ORCID: https://orcid.org/0000-0002-3848-3357)
- Robert B. Rebhun (ORCID: https://orcid.org/0000-0002-8047-3494)
- Marshall Lammers (ORCID: https://orcid.org/0000-0003-2237-847X)
- Robert J. Canter (ORCID: https://orcid.org/0000-0002-3331-5418)
- Sean J. Judge (ORCID: https://orcid.org/0000-0002-1842-9468)
- Alicia A. Gingrich (ORCID: https://orcid.org/0000-0002-7239-0154)
- C Titus Brown
Institutions
- University of Wisconsin–Madison (US)
- University of California Davis Medical Center (US)
- University of California, Davis (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1571085
- Citations
- 7
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Cancer Research Coordinating Committee
- National Institutes of Health
- University of California, Davis
- National Cancer Institute
- Genome Center, University of California, Davis
- Comprehensive Cancer Center, University of California, Davis