IL6/CCL2 from M2-polarized microglia promotes breast cancer brain metastasis and the reversal effect of β-elemene
Our work first demonstrated that β-elemene regulated the IL6/STAT3 axis and M-MDSC recruitment to reconstruct immunosuppressive brain microenvironment to suppress BC-BM.
Authors
- Xueyu Wang (ORCID: https://orcid.org/0000-0002-5301-0216)
- Qian Feng
- Rong-Rong Zhang (ORCID: https://orcid.org/0000-0002-8876-1618)
- Rong Zhang (ORCID: https://orcid.org/0000-0002-9872-2954)
- Yihua Zou (ORCID: https://orcid.org/0000-0003-4963-2757)
- Cai-Zhi Li
- Zhongqiu Liu (ORCID: https://orcid.org/0000-0001-6986-9677)
- Xia Yang (ORCID: https://orcid.org/0000-0003-0612-7523)
Institutions
- Guangzhou University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.3389/fphar.2025.1547333
- Citations
- 5
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province