Overexpression of MAFG-AS1 in ovarian cancer promotes glucose metabolism reprogramming and malignant biological behavior of ovarian cancer cells by regulating HIF-1α
Our study revealed silencing MAFG-AS1 could inhibit the proliferation and induce apoptosis of OC cells by inhibiting the HIF-1α-mediated glycolysis process. Therefore, this study further potentially reveals the machinery of MAFG-AS1 in regulating OC cell proliferation and apoptosis, which is expected to provide a theoretical basis for the study of new targets.
Authors
- Fei Yu (ORCID: https://orcid.org/0000-0003-1546-9365)
- Jia Liu (ORCID: https://orcid.org/0000-0001-6952-7175)
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1007/s12672-025-02429-y
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94