Development and Evaluation of Diclofenac Sodium Cream and Its Released Studies

Objective: This study aimed to develop and evaluate diclofenac sodium cream and it’s in vitro rerelease studies with various enhancers.Methodology: Various formulations of diclofenac cream were developed with good solubility excipients and various enhancers. For in vitro release studies Franz diffusion cell with cellulose membrane and spectrophotmetric method were used for analysis. The study used sophisticated advanced techniques including Diffraction (XRD) Scanning Electron Microscopy (SEM) and Transform Infrared Spectroscopy (FTIR) to examine the physicochemical properties of the cream. The study included physical evaluations of the cream as well as measurements of its pH level and drug content, stability study and skin irritation was performed.Results: The transdermal delivery of diclofenac sodium showed significant improvement when penetration enhancers were added. Formulation F1 and F2 showed best released (71.993-72.83%).The enhanced permeation in a pattern DMSO>Thymus oil >Clove oil >castor oil> Ethanol, demonstrates that the diclofenac cream formulation successfully by passes the membranes to deliver medication more effectivelyConclusion: Penetration enhancers in diclofenac sodium cream formulation lead to a significant increase in skin absorption. Researchers demonstrated that this method holds potential for creating successful formulations for topical pain treatment options.