Genome-Wide Methylation Sequencing to Identify DNA Methylation Markers for Early-stage Hepatocellular Carcinoma in Liver and Blood
DNA methylation patterns in liver tissue were distinctly different between HCC and controls. In blood, DMMs contributed minimally to early-stage HCC detection compared to cirrhosis, whether used alone or in combination with the ASAP/GAAD score. It is likely that high baseline DNA methylation related to cirrhosis and possibly the low input of tumor-related DNA impacts the use of DMMs in early HCC detection in blood.
Authors
- André Boonstra (ORCID: https://orcid.org/0000-0001-8607-1616)
- Roeland F. de Wilde (ORCID: https://orcid.org/0009-0003-0444-8697)
- Ruben Boers (ORCID: https://orcid.org/0000-0002-3377-2897)
- Dave Sprengers (ORCID: https://orcid.org/0000-0003-4280-4210)
- Joachim Boers (ORCID: https://orcid.org/0000-0001-5016-4829)
- Vanja de Weerd
- Bettina E. Hansen (ORCID: https://orcid.org/0000-0001-8307-3341)
- José D. Debes (ORCID: https://orcid.org/0000-0002-1512-2604)
- Maurice Jansen (ORCID: https://orcid.org/0000-0003-0045-1584)
- Saskia M. Wilting (ORCID: https://orcid.org/0000-0002-2838-841X)
- Jean Helmijr (ORCID: https://orcid.org/0000-0003-0983-6296)
- Joost H. Gribnau (ORCID: https://orcid.org/0000-0001-5645-4691)
- Pam Elisabeth van der Meeren (ORCID: https://orcid.org/0009-0007-5607-8092)
- Michail Doukas (ORCID: https://orcid.org/0000-0002-8611-840X)
- Siyu Fu
Institutions
- University of Minnesota (US)
- University Health Network (CA)
- University of Toronto (CA)
- Erasmus MC (NL)
- Erasmus MC Cancer Institute (NL)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s13046-025-03412-9
- Citations
- 6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 4.84