Silencing of SCEL promotes progression of oral squamous cell carcinoma via activating TGF-β/Smad pathway
SCEL acts as a tumor suppressor in OSCC, influencing its progression and potential metastasis. Loss of SCEL facilitates OSCC progression by activating TGF-β/Smad signaling. Upregulating SCEL and silencing miR-5696 hold therapeutic promise for OSCC.
Authors
- Liudmila Matskova
- Jun Zhao (ORCID: https://orcid.org/0000-0001-8903-8205)
- Xiaoying Zhou (ORCID: https://orcid.org/0000-0003-3298-5089)
- Danping Li (ORCID: https://orcid.org/0000-0002-4196-4055)
- Limei Li (ORCID: https://orcid.org/0000-0002-2728-5072)
- Yingxi Mo (ORCID: https://orcid.org/0009-0008-3415-5998)
- Haishan Zhang (ORCID: https://orcid.org/0000-0001-7657-5984)
- Ping Li (ORCID: https://orcid.org/0000-0002-6118-3483)
- Shu Wu
- Qiaoli Chen
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- Karolinska Institutet (SE)
- Federal Research Center of Fundamental and Translational Medicine (RU)
- Institute of Molecular Biology and Biophysics (RU)
- Tumor Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1007/s12672-025-02423-4
- Citations
- 3
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 3.14