Antidepressant Remission and Manic Switch in Bipolar Depression: A Propensity Score Analysis
With PS adjustment, there was no evidence of increased likelihood of manic switch or achievement of symptomatic remission associated with antidepressant use in bipolar depression. Our results underscore the ongoing need to identify alternative strategies for effective treatment of bipolar depression.
Authors
- Bárbara A. Palma
- Sergio Barroilhet (ORCID: https://orcid.org/0000-0002-2016-3662)
- Roy H. Perlis (ORCID: https://orcid.org/0000-0002-5862-6757)
- Paul A. Vöhringer (ORCID: https://orcid.org/0000-0002-2460-4680)
Institutions
- Tufts University (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Millennium Institute for Research in Depression and Personality (CL)
- Hospital Clínico de la Universidad de Chile (CL)
- University of Chile (CL)
Publication Details
- Journal
- Acta Psychiatrica Scandinavica
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1111/acps.13822
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Mental Health