What is the correlation between the results of the intraoperative histopathological consultation and the final pathological examinations in uterine cancer patients? Results and retrospective analysis of 218 cases

Background: Endometrial carcinoma (EC) is the most common gynecological malignancy in developed countries. For optimal treatment, the clinicopathological characteristics of EC need to be revealed. This study aimed to evaluate the compatibility of intraoperative frozen section (IFS) and final diagnostic results. Methods: In this study, two hundred and eighteen EC patients, who were operated on for EC between 2008 and 2018, were evaluated retrospectively. The IFS and final diagnosis results of the patients were compared in terms of myometrial invasion (MI), cervical invasion, tumor size, histological subtype and grade, and the concordance rate between IFS and final diagnosis was calculated. Results: One hundred thirty-nine patients were included in the study. The average age of the patients was 57.60 ± 10.41 years, the average body mass index (BMI) was 37.82 ± 8.75 kg/m2, and the average surgery duration was 258.24 ± 151.30 minutes. The concordance between IFS and final diagnosis was 81.3%, 88.5%, 89.2%, 71.9% and 95.9% for tumor histology, tumor grade, MI, tumor diameter and cervical involvement, respectively. None of the 139 patients received unnecessary treatment, three patients received inadequate treatment due to MI, and seven patients received inadequate treatment due to grade incompatibility. Conclusions: The compliance results of our study suggest that IFS is a good indicator for decisions about the appropriate surgical procedure.