Increased excitability of dentate gyrus mossy cells occurs early in life in the Tg2576 model of Alzheimer’s disease
Alterations in Tg2576 MCs and GCs early in life suggest an early role for MCs in increased GC excitability. MCs may be a novel target to intervene in AD pathophysiology at early stages.
Authors
- Justin J. Botterill (ORCID: https://orcid.org/0000-0002-3141-2281)
- Helen E. Scharfman (ORCID: https://orcid.org/0000-0003-4006-3383)
- David Alcantara‐Gonzalez (ORCID: https://orcid.org/0000-0002-1944-6163)
- Meghan Kennedy
- Chiara Criscuolo (ORCID: https://orcid.org/0000-0002-1080-9941)
Institutions
- Nathan Kline Institute for Psychiatric Research (US)
- University of Saskatchewan (CA)
- NYU Langone Health (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s13195-025-01747-1
- Citations
- 4
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- Alzheimer's Association
- New York State Office of Mental Health
- National Institutes of Health