Advances in the Study of Metabolic Interactions between Bile Acids and Gut Microbes and Their Regulatory Role in Disease Development

胆汁酸是一种由肝脏合成，通过肠肝循环维持稳态的化合物。由于近年来对微生物的研究手段不断更新，研究结果不断涌现，人们逐渐认识到胆汁酸与肠道微生物的关联。本文聚焦胆汁酸与肠道微生物的代谢关系及其对疾病的影响，肠道微生物与胆汁酸之间的代谢调节作用，以及与该稳态相关的影响因素，以期为该领域学者提供相关知识图谱，为临床治疗带来新方向。Bile acids are compounds synthesized by the liver and maintained in homeostasis through the enterohepatic circulation. Due to the continuous updates of research methods on microorganisms in recent years and the continuous emergence of research results, people have gradually come to recognize the association between bile acids and gut microbiota. This article focuses on the metabolic relationship between bile acids and gut microbiota and its impact on diseases, the metabolic regulation between gut microbiota and bile acids, as well as the influencing factors related to this homeostasis. It is hoped that this can provide relevant knowledge map for scholars in this field and bring new directions for clinical treatment.