Group-Directed [5+2] Cycloaddition Approach to 10π-Electron Cyclohepta[<i>c</i>]furans and Derivatives
We present a group-assisted protocol that enables the 1,3-dien-5-yne scaffold as a novel five-carbon synthon to accomplish a palladium-catalyzed [5+2] cycloaddition with a variety of alkynes in the presence of H<sub>2</sub>O. This method affords a straightforward approach to the synthesis of 10π-electron 6<i>H</i>-cyclohepta[<i>c</i>]furans that are versatile building blocks for constructing diverse cycloheptatriene-fused molecular architectures.
Authors
- Tianyong Hou (ORCID: https://orcid.org/0000-0002-7685-2088)
- Wenpeng Lü (ORCID: https://orcid.org/0000-0002-1840-3540)
- Yi Yang (ORCID: https://orcid.org/0000-0002-7775-6856)
- Zhen Zhang (ORCID: https://orcid.org/0009-0003-2709-6997)
- Cheng Ma (ORCID: https://orcid.org/0000-0002-2456-6725)
Institutions
- Zhejiang University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1021/acs.orglett.5c01515
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China