A Comprehensive Systematic Review of Tridax procumbens. L on Wound Healing and Its Pharmacological Aspects

Tridax procumbens. Linn is a well-known medicinal plant found all over India. It contains flavonoids, alkyl esters, sterols, pentacyclic triterpenes, fatty acids and polysaccharides, and various chemical constituents naturally. The extracts obtained from Tridax leaves promote wound healing activity with VEGF (Vascular Endothelial Growth Factor) signaling pathway. The wound healing is induced by increased lysyl oxidase activity (encoded by LOX gene) by Tridax. This study reveals the stages of wound healing activity includes fibroblastic proliferation and muco polysaccharides production, replacement of muco polysaccharides with collagen molecules and cross-linking of collagen fibers, and collagen fiber shrinkage. Its effects such as anti-cancer, anti-fungal and anti-hypersensitive activity are discussed briefly. The aqueous, methanolic and ethanolic extract of Tridax procumbens has a significant anti-diabetic activity. The chloroform extract from the aerial parts of the plant plays a pivotal role as a curative drug for liver damage with increased levels of Aspartate transaminase (AST), lactate dehydrogenase, gamma-glutamyl transferase and bilirubin.