AEOL-induced NRF2 activation and DWORF overexpression mitigate myocardial I/R injury
Taken together, our study reveals that AEOL-induced NRF2-mediated overexpression of DWORF enhances myocardial function through the activation of the SERCA2a offering promising therapeutic avenues for mI/R injury.
Authors
- Antonio Lax (ORCID: https://orcid.org/0000-0001-5452-8781)
- Silvia Pascual-Oliver
- Miriam Ruiz Ballester (ORCID: https://orcid.org/0000-0002-8002-5253)
- Yassine Sassi (ORCID: https://orcid.org/0000-0002-7807-1728)
- M. Lopez
- Domingo A. Pascual‐Figal (ORCID: https://orcid.org/0000-0002-4993-9540)
- Fernando Soler (ORCID: https://orcid.org/0000-0001-7431-3665)
- José J. Fuster (ORCID: https://orcid.org/0000-0002-5970-629X)
- Francisco Jose Bastida-Nicolas
Institutions
- Spanish National Centre for Cardiovascular Research (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Spanish National Centre for Cardiovascular Research (ES)
- Biomedical Research Institute (US)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Hospital Universitario Virgen de la Arrixaca (ES)
- Universidad de Murcia (ES)
- Virginia Tech (US)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1186/s10020-025-01242-1
- Citations
- 5
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 6.94
Funders
- Fundación Mutua Madrileña
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Universidad de Murcia
- Centro Nacional de Investigaciones Cardiovasculares
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación