Elevated Plasma MBL Levels Are Associated With Risk of Future Venous Thromboembolism: The HUNT Study
Our findings support the notion that high plasma MBL levels are associated with an increased risk of future VTE and suggest that the risk increase is partially mediated through the initiation of thrombin generation by MBL-MASP-1/2 complexes at the site of venous thrombosis formation.
Authors
- Steven P. Grover (ORCID: https://orcid.org/0000-0001-8709-8394)
- Gábor Pál (ORCID: https://orcid.org/0000-0001-7868-7971)
- Kristian Hveem (ORCID: https://orcid.org/0000-0001-8157-9744)
- Tom Eirik Mollnes (ORCID: https://orcid.org/0000-0002-5785-802X)
- Péter Gál (ORCID: https://orcid.org/0000-0001-8987-2080)
- Christian Jonasson (ORCID: https://orcid.org/0000-0002-7694-6025)
- Kristian Hindberg (ORCID: https://orcid.org/0000-0002-8194-6679)
- John‐Bjarne Hansen (ORCID: https://orcid.org/0000-0003-4854-3162)
- Therese Haugdahl Nøst (ORCID: https://orcid.org/0000-0001-6805-3094)
- Christabel Esi Damoah (ORCID: https://orcid.org/0000-0001-6635-5128)
- Sigrid Kufaas Brækkan (ORCID: https://orcid.org/0000-0002-9678-9696)
- Omri Snir (ORCID: https://orcid.org/0000-0001-5322-0021)
- Peter Garred (ORCID: https://orcid.org/0000-0002-2876-8586)
- Solveig M. Valderhaug
Institutions
- Eötvös Loránd University (HU)
- University of North Carolina at Chapel Hill (US)
- Oslo University Hospital (NO)
- University of North Carolina Health Care (US)
- Norwegian University of Science and Technology (NO)
- Levanger Hospital (NO)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Nordland Hospital (NO)
- Thrombosis Research Institute (GB)
- UiT The Arctic University of Norway (NO)
- HUN-REN Research Centre for Natural Sciences (HU)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1161/atvbaha.124.322052
- Citations
- 2
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.59