SM22α-Lineage Perivascular Stromal Cells Contribute to Abdominal Aortic Aneurysm
PGC-1α deficiency in SM22α-lineage PVSCs disrupts the balance between adipogenic and myofibrogenic differentiation through regulating YAP signaling, ultimately promoting AAA development. Radiomics assessment may present a promising noninvasive approach for PVAT evaluation in aneurysms, offering valuable potential for clinical research.
Authors
- Aijun Sun (ORCID: https://orcid.org/0000-0003-1488-0937)
- Lichi Zhang (ORCID: https://orcid.org/0000-0003-4396-4566)
- Zhiyun Song
- M.-F. Li (ORCID: https://orcid.org/0009-0003-0315-2464)
- Hongjin Chen (ORCID: https://orcid.org/0009-0002-1820-2244)
- Bingling Lu
- Tomasz J. Guzik (ORCID: https://orcid.org/0000-0002-5039-7849)
- Run Zhang (ORCID: https://orcid.org/0000-0002-0943-824X)
- Fuhua Yan (ORCID: https://orcid.org/0000-0002-5910-1506)
- Zhe Wang
- Siyuan Chen (ORCID: https://orcid.org/0000-0003-0219-3558)
- Xiaoxi Pan
- Fang Wu (ORCID: https://orcid.org/0000-0001-5268-9098)
- Le Qin (ORCID: https://orcid.org/0000-0002-8244-8217)
- Yi Yang (ORCID: https://orcid.org/0000-0001-8913-0220)
- Pingjin Gao (ORCID: https://orcid.org/0000-0002-7750-3314)
- Ji‐Guang Wang
Institutions
- Jagiellonian University (PL)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Ruijin Hospital (CN)
- Zhongshan Hospital (CN)
- Shanghai Institute of Hypertension (CN)
- Shanghai Clinical Research Center (CN)
- The Queen's Medical Research Institute (GB)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1161/circresaha.124.325750
- Citations
- 14
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 19.43