Platelet-Derived PDGF-A Disrupts Blood-Brain Barrier Integrity in Ischemic Stroke—Brief Report
PDGF-A released from platelets impairs blood-brain barrier integrity, resulting in detrimental vascular leakage and infarct progression. These findings provide important insights on the pivotal role of platelets in IS further elucidating the mechanisms of thrombo-inflammation in the brain.
Authors
- Michael Klaus Schuhmann (ORCID: https://orcid.org/0000-0002-4014-7010)
- Katrin G. Heinze (ORCID: https://orcid.org/0000-0003-2372-6800)
- Vanessa Göb (ORCID: https://orcid.org/0000-0003-0813-8680)
- Katherina Hemmen (ORCID: https://orcid.org/0000-0003-1852-6513)
- Axel Haarmann (ORCID: https://orcid.org/0000-0002-5597-6225)
- Lena Zimmermann (ORCID: https://orcid.org/0000-0003-4350-3655)
- David Stegner (ORCID: https://orcid.org/0000-0003-1059-9865)
Institutions
- University of Würzburg (DE)
- Universitätsklinikum Würzburg (DE)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1161/atvbaha.125.321191
- Citations
- 6
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 8.13