<i>Rpl13a</i> snoRNAs <i>U34</i> and <i>U35a</i> : New Targets for Sickle Cell Disease Complications
<i>Rpl13a</i> snoRNAs <i>U34</i> and <i>U35a</i> specifically increase ROS levels, which, in turn, regulate snoRNA expression, in sickle erythroid cells, modulating Prdx2 expression/activity, subsequently impairing hemodynamics. Targeted U34+<i>U35a</i> with antisense oligonucleotide may represent a novel and safe therapy to ameliorate erythropoiesis and downstream events in SCD.
Authors
- Waseem Chauhan (ORCID: https://orcid.org/0000-0002-8980-8406)
- Shirin Ferdowsi (ORCID: https://orcid.org/0000-0002-3998-7290)
- Sushmit Kafle
- Sudharshan SJ
- Rahima Zennadi
Institutions
- University of Tennessee Health Science Center (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1161/circresaha.124.325093
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00