IL-19 Is a Novel Lymphangiocrine Factor Inducing Lymphangiogenesis and Lymphatic Junctional Regulation
Taken together, these data show that IL-19 has potent effects on lymphatic vessel formation and function in vitro and that IL-19 regulates lymphatic drainage in vivo. IL-19 may represent an immunomodulatory cytokine with therapeutic potential for improving impaired lymphatic function consequent to inflammation.
Authors
- Silvia Fossati (ORCID: https://orcid.org/0000-0002-2047-222X)
- Michael V. Autieri (ORCID: https://orcid.org/0000-0003-1039-7577)
- Amanda Peluzzo (ORCID: https://orcid.org/0000-0002-5822-3480)
- Cali Corbett (ORCID: https://orcid.org/0000-0002-8687-6972)
- Amanda St. Paul (ORCID: https://orcid.org/0000-0002-9778-8652)
- Xiaolei Liu (ORCID: https://orcid.org/0000-0002-6881-3716)
- Sheri Kelemen
Institutions
- Lymphatic Education & Research Network (US)
- Temple University (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1161/atvbaha.125.322669
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00