Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis
Anti-EPCR and anti-αvβ6 each strongly predict UC onset. The combined anti-EPCR and anti-αvβ6 model had stronger predictive performance than the single models.
Authors
- Taku Obara (ORCID: https://orcid.org/0000-0002-3674-1674)
- Kazuki Kumada (ORCID: https://orcid.org/0000-0002-2970-7742)
- Atsushi Hozawa (ORCID: https://orcid.org/0000-0002-8031-8523)
- Hideya Iwaki
- Kinuko Ohneda (ORCID: https://orcid.org/0000-0002-6919-6529)
- Takeo Naito (ORCID: https://orcid.org/0000-0002-6249-2536)
- Soshi Okazaki
- Yoichi Kakuta (ORCID: https://orcid.org/0000-0002-7042-009X)
- Yoshitaka Kinouchi (ORCID: https://orcid.org/0000-0002-3368-8855)
- Atsushi Masamune (ORCID: https://orcid.org/0000-0001-7184-7282)
- Soichi Ogishima (ORCID: https://orcid.org/0000-0001-8613-2562)
- Hiroshi Fujii (ORCID: https://orcid.org/0000-0002-6885-6492)
- Rintaro Moroi (ORCID: https://orcid.org/0000-0002-6759-0135)
- Yusuke Shimoyama (ORCID: https://orcid.org/0009-0005-1133-7754)
- Hisaaki Kudo (ORCID: https://orcid.org/0000-0002-4477-7095)
- Hisashi Shiga (ORCID: https://orcid.org/0000-0001-6623-2603)
- Tsuyoshi Shirai (ORCID: https://orcid.org/0000-0002-6295-3494)
- Fuji Nagami (ORCID: https://orcid.org/0000-0002-3652-9788)
- Masatsugu Orui (ORCID: https://orcid.org/0000-0002-4871-8455)
- Motoi Sawahashi
- Hiroshi Nagai (ORCID: https://orcid.org/0009-0000-8782-1909)
Institutions
- Tohoku University (JP)
- Tohoku University Hospital (JP)
- Tohoku Medical Megabank Organization (JP)
Publication Details
- Journal
- Journal of Gastroenterology
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1007/s00535-025-02263-7
- Citations
- 5
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 9.09
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology